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| Figure 2: Effect of Securigera securidaca methanol extract, Kaempferol, kaempferol 7-O-glycoside , and ACV on HSV-1 replication in Vero cells. The 50% inhibitory concentration (EC50) of each extract was calculated using regression line. Each bar represents the mean ± SD of three independent experiments. (*) There is a significant difference between test extract and solvent control (p < 0.05). EC50 values of crude methanol extract, kaempferol, kaempferol-7-Oglucoside and acyclovir (ACV) were 2 ± 0.12, 0.2 ± 0.01, 0.1 ± 0.01 and 0.1 ± 0.01 μg/mL, respectively. The calculated selective index (SI) for methanol extract and kaempferol and kaempferol-7-O-glycoside was 125, 300 and 5000 respectively. |
