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| Figure 5: Protection of unmodified HIV target cells by sscFvPRO140. (a) Reduction of HIV entry mediated by sscFvPRO140. Single-round infection assays were performed with R5 HIVJRFL Env-pseudotyped reporter vector particles expressing dsRed in the presence of increasing concentrations of purified sscFvPRO140 or (b) culture supernatant containing 90 nM sscFvPRO140 (Sn 2). Supernatant from cell transduced with LVX vector particles served as a control (Sn 1). A relative infection of 100% corresponded to 20% of infected cells (a and b); n=2, *p<0.05. |
