Structure Base EC50(μM) CC50(μM) SI(CC50/EC50)
4’MdN Ad
Th
Cy
Purine		 2.6
7.2
0.072
1.9		 2.6
104
0.13
>200		 1.0
-
1.8
>100
4’Md4N Ad
Th
Cy		 >500
21
350		 >500
330
350		 ~1
16
-
4’MddN Ad
Th
Cy		 30
>500
27		 400
>500
27		 13
~1
1
AZT
ddA
d4T		 0.001
47
4.1		 >20
>500
>500		 >2020
>11
>120
EC50=50% effective concentration; CC50=Cytotoxic concentration; SI-Selectivitiy index (CC50/EC50); 4’MdN=4’=C-methyl-2’-deoxynucleoside; 4’Md4N=4’-C-methyl- 2’-3’-didehydrodi deoxynucleoside; 4’MddN=4’-C-methyl-2’-3’-dideoxy nucleoside; AZT=3’-azido-3’deoxythymidine; ddA=2’,3’-dideoxyadenosine; d4T=2’,3’- didehydro-3’-deoxythymidine
Table 1: Anti-HIV activety of 4’-C-methyl-2’-deoxynucleosides.
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