Compound Base EC50(μM)a) CC50(μM) S.I. 4’-C-Cyano-2’-deoxypurine A 0.051 12 235 I 0.051 23 451 2AAb) 0.00079 0.034 43 G 0.000188 0.034 181   A 0.098 16 1630   I 0.15 216 1440   2AA 0.0003 0.82 2733   G 0.0014 1.5 975 AZT 0.0032 29.4 9190 a) Anti-HIV activity was determined by MTT assay. MT-4 cells and HIV-1LAI were employed b) 2-aminoadenine

Table 3: Anti-HIV activity of 4’-C-cyano-2’-deoxypurines and 4’-C-ethynyl-2’- deoxypurines.

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