Table 4 | Anti-HIV activity of selected 4’SdNs..

Compound	EC₅₀(μM)^a)
Compound	HXB2^b)	KH65R	L74V	4l/2l5	Ml84V	Ml84I	4l/69/125/SG	MDR^d)	Yl8lC	CC₅₀(μM)
4’EdC	0.0012	0.0008	0.0013	0.006	0.0024	0.0026	0.015	0.0012	0.0021	>200
4’EaraC	0.0071	0.015	0.026	0.026	0.71	0.48	0.17	0.0079	0.016	>200
4’MedC	0.0058	0.0071	0.0062	ND	0.2	0.74	ND	0.0033	ND	>200
4’EdA	0.008	0.0033	0.004	0.012	0.047	0.022	0.065	0.0062	0.011	>200
4’Ed2AA	0.0014	0.00035	0.0007	0.0017	0.0059	0.0027	0.0041	0.001	0.0008	>200
4’EdG	0.007	0.001	0.0012	0.019	0.008	0.0041	0.0068	0.0048	0.01	52
4’EdI	0.81	0.25	0.61	1.3	1.6	1.5	2.2	0.51	ND	>200
AZT	0.022	0.02	0.02	0.3	0.01	0.017	1.6	15.3	0.014	>100
3TC	0.71	ND	ND	ND	>100	>100	9.9	1.1	ND	>100
ddC	0.2	3.0	1.5	ND	2.2	ND	1.3	5.5	ND	>100
ddI	3.9	12.7	19.5	3.6	10.1	ND	12.2	25	ND	>100

Anti-HIV activity was determined with MAGI assay, ND: not determined. b) wild type HIV. d) multidrug-resistant HIV

Table 4: Anti-HIV activity of selected 4’SdNs against wild type HIV and drug-resistant HIVs.

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