Intravenous administration Oral administration
Dose (mg/Kg) Mortality (%) Dose (mg/Kg) Mortality (%)
4’EdA and 4’EdI 100
10
3
1		 0
0
0
0		 100
10
3
1		 0
0
0
0
4’Ed2AA 100
10
3
1		 100 (1 day)b)
100 (2 days)
0
0		 100
10
3
1		 100 (1 day)
100 (2 days)
100 (2 days)
0
4’EdG 100
10
3
1		 100 (1 day)
100 (2 days)
100 (4 days)
0		 100
10
3
1		 100 (1 day)
100 (4 days)
100 (4 days)
0
a) Six-week-old ICR male mice were employed.
b) Numbers in parentheses represent survival days of mice after administration
Table 5: Toxicity of purine derivatives of 4’-C-ethynyl-2’-deoxynucleosides to micea).
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