EFdA ECldA Ed4FA EddFA Ed4T Compound Anti HIV activity (Magi assay, μM) HIV-1wild HIV-1MDR HIV-1M184V SI EFdA 0.00020 0.00014 0.0031 110,000 ECldA 0.0019 0.0084 0.01 330,000 Ed4FA 0.80 0.15 1.8   EddFA 0.94 8.7 97   AZT 0.17 74.3 0.13   3TC 1.0 2.8 >100   Ed4T 1.5 1.1 17 >50,000 d4T 7.6 64 5.6   MAGI = multinuclear activation of galactosesidase indicator, HIV = human immune deficiency virus, AZT = 3’-azido-3’-deoxythymidine; 3TC = 2’,3’-dideoxy-3’-thia-Lcytidime; d4T = 2’,3’-didehydrodideoxythymidine.

Table 6: Anti HIV activity of 4’-C-substituted-2’-deoxy-2-haloadenosines.

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