| Animal Group |
Route of Entry |
Dosage |
Life Expectancy (X ± m), days |
ILE(in % as compared to controls) |
| LiCl(I)I2DP |
o |
5.0 ml/kg |
13.0 ± 1.7 |
4.0 |
| 10.0 ml/kg |
13.5 ± 1.8 |
8.0 |
| 15.0 ml/kg |
14.1 ± 2.0 |
12.8 |
| Doxorubicin |
abd |
1.5 m/kg |
36.0 ± 2.3 |
188.0* |
| Controls |
o |
15.0 ml/kg |
12.5 ± 1.6 |
- |
| LiCl(I)I2DP + Doxorubicin, at the same time |
o + abd |
5.0 ml/kg + 1.5 m/kg |
46.0 ± 7.1 |
268.0** |
| 10.0 ml/kg + 1.5 m/kg |
43.1 ± 3.0 |
244.8** |
| 15.0 ml/kg + 1.5 m/kg |
27.0 ± 11.0 |
116.0* |
| LiCl(I)I2DP + Doxorubicin, in 6 hours |
o + abd. |
5.0 ml/kg + 1.5 m/kg |
40.3 ± 7.0 |
222.4* |
| 10.0 ml/kg + 1.5 m/kg |
36.5 ± 7.2 |
192.0* |
| 15.0 ml/kg + 1.5 m/kg |
27.6 ± 9.9 |
120.8* |
| LiCl(I)I2DP + Doxorubicin, in 6 hours |
abd + o |
1.5 m/kg + 5.0 ml/kg |
43.1 ± 5.1 |
244.8** |
| 1.5 m/kg +10.0 ml/kg |
39.5 ± 7.7 |
216.0* |
| 1.5 m/kg +15.0 ml/kg |
32.6 ± 11.4 |
160.8* |
| LiCl(I)I2DP |
abd |
1.0 ml/kg |
13.4 ± 1.7 |
0 |
| 2.0 ml/kg |
14.5 ± 2.8 |
4.3 |
| 3.0 ml/kg |
14.0 ± 3.2 |
0.7 |
| Doxorubicin |
abd |
1.5 m/kg |
39.6 ± 7.2 |
184.9* |
| Controls |
abd |
3.0 ml/kg |
13.9 ± 1.2 |
- |
| LiCl(I)I2DP + Doxorubicin at the same time |
abd +abd |
1.0 ml/kg + 1.5 m/kg |
52.4 ± 9.0 |
276.9** |
| 2.0 ml/kg + 1.5 m/kg |
48.4 ± 4.2 |
248.2** |
| 3.0 ml/kg + 1.5 m/kg |
35.4 ± 9.2 |
154.7* |
| LiCl(I)I2DP + Doxorubicin, in 6 hours |
abd + abd. |
1.0 ml/kg + 1.5 m/kg |
41.1 ± 3.3 |
195.7* |
| LiCl(I)I2DP + Doxorubicin, in 6 hours |
abd + abd. |
1.0 ml/kg + 1.5 m/kg |
41.1 ± 3.3 |
195.7* |
| 2.0 ml/kg + 1.5 m/kg |
39.3 ± 5.0 |
182.7* |
| 3.0 ml/kg + 1.5 m/kg |
28.3 ± 13.1 |
82.0* |
| LiCl(I)I2DP + Doxorubicin, in 6 hours |
abd. + abd. |
1.5 m/kg + 1.0 ml/kg |
42.0 ± 8.3 |
202.2 * |
| 1.5 m/kg + 2.0 ml/kg |
38.0 ± 8.7 |
173.4* |
| 1.5 m/kg + 3.0 ml/kg |
27.4 ± 11.1 |
97.1* |
