Table 1 | Antiviral Activity of GS-9224 in Various..

Compound	Anti-HIV in MT2^a	Cytotoxicity in MT2^a	Anti-HIV in MT4^a	Cytotoxicity in MT4^a	Anti-HIVin PBMC^b	Cytotoxicityin PBMC^b
Compound	EC₅₀ (nM)	CC₅₀(nM)	EC₅₀ (nM)	CC₅₀ (nM)	EC₅₀ (nM)	CC₅₀ (nM)
GS-9224	1.3 ± 1.1	1600 ± 600	9.4 ± 0.5	700 ± 300	5 ± 6	5850 ± 900
GS-9160	1.2 ± 0.5	4200 ± 1000	4 ± 3	800 ± 400	1.2 ± 0.9	3880 ± 1700
RAL	7.5 ± 1	>100,000	8 ± 2	58200 ± 7300	2.6 ± 1.2	210,500 ± 90,000

^aMean ± SD of at least 4 independent experiments.
^b Mean ± SD of at least 3 different donors

Table 1: Antiviral Activity of GS-9224 in Various HIV-1 Infected Human Cell Types.

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