Table 3 | Inhibition of Integrase Enzymatic Strand..

Compound	Strand Transfer^a	2LTR Circles in SupT1^b		Cytotoxicity in SupT1^c	Late RT in MT-2^b	Alu-LTR in MT-2^b	Cytotoxicity in MT-2^c
Compound	IC₅₀ (nM)	MaximumFold-Change	EC₅₀ (nM)	CC₅₀ (nM)	EC₅₀ (nM)	EC₅₀ (nM)	CC₅₀ (nM)
GS-9224	55 ± 10	3.9 ↑	9.5	2600	>100	2.8	1600
GS-9160	29 ± 3	2.3 ↑	11	970	>100	1.8	4200
RAL	34 ± 5	2.4 ↑	12	>100,000	>200	3.6	>100,000
EFV	–	0.2 ↓	1.5	14000	3.5	1.3	>27,000
APV	–	1 ↔	–	83000	>500	>500	>50,000

^aMean ± SE of at least 4 independent experiments using IN enzyme.
^b Mean of at least 2 independent experiments in HIV-1 infected SupT1 or MT-2 cells.
^cMean of at least 4 independent experiments in uninfected SupT1 or MT-2 cells.

Table 3: Inhibition of Integrase Enzymatic Strand Transfer Activity and Integration in HIV-1 Infected SupT1 and MT-2 Cells.

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