| Compound |
EC50 , nM (fold change relative to HIV-1 IIIb |
| HIV-1 IIIba |
GS-9224 P4 Virusb |
GS-9224 P6 Virusb |
| TFV |
3.8 ± 0.8 |
3 ± 0.4 (0.9) |
5.9 ± 0.9 (1.6) |
| EFV |
0.7 ± 0.1 |
1.3 ± 0.2 (1.9) |
1.5 ± 0.3 (2.2) |
| LPV |
13.0 ± 4.0 |
27.0 ± 6.0 (2.1) |
20.9 ± 0.8 (1.6) |
| RAL |
3.5 ± 0.6 |
11.0 ± 1.2 (3.1) |
237.0 ± 126.0 (>100) |
| GS-9224 |
4.0 ± 2.0 |
18.6 ± 2.7 (4.6) |
>1000 (>100) |
|
a Mean ± SD of at least 6 independent experiments.
b Mean ± SD of at least 3 independent experiments.
The numbers in parentheses represent the fold-change over wild-type virus. |
| Table 5: Resistance Phenotype of GS-9224 Selected Viral Pools. |
