Table 6 | Resistance Profile of Mutant Viruses..

Compounds^d	EC50 (nM)	Fold-Change in EC₅₀ Relative to HIV-1 III^b
Compounds^d	HIV-1 III^b	L74M^a	G140S^b	Q148K^c	L74M/G140S	L74M/G140S/Q148K
RAL	4.3	1.7	2	136	3	32
GS-9160	1.7	1	6	28	19	455
GS-9224	5.6	1	6	42	11	118

^a Selected by GS-9224 (this report), L-708,906 (32), S-1360 (33), L-870,810 (42) and GS-9160 (19).
^b Selected by GS-9224 (this report) and L-Chicoric acid (29).
^c Selected by GS-9224 (this report), S-1360 (31) and RAL (14, 39).
^d The EC50 and fold-change represent the mean of a least two independent experiments performed in triplicate.

Table 6: Resistance Profile of Mutant Viruses Selected by GS-9224

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