| UGT Isoform |
GucuronidationRatea,b (pmol/min/mg) |
| 1A1 |
1A3 |
1A4 |
1A6 |
1A7 |
1A8 |
1A9 |
2B4 |
2B7 |
2B15 |
2B17 |
| GS-9160 |
16.7 |
17.5 |
0.2 |
1.5 |
<0.02 |
1.9 |
1.9 |
<0.02 |
<0.02 |
<0.02 |
0.1 |
| GS-9224 |
75.4 |
32.0 |
<0.02 |
<0.02 |
<0.02 |
1.6 |
1.3 |
<0.02 |
<0.02 |
0.2 |
<0.02b |
|
a Mean of duplicate test.
bThe Limit of rate detection is 0.02 pmol/min/mg |
| Table 8: Rate of Glucuronidation of GS-9224 by Major UGT Isoforms. |
