| Newer ARTs |
CYP involved in metabolism of newer ARTs |
Effect of drugs of abuse on CYP expression |
Drug-drug interactions |
| CCR5 antagonists |
|
Induction of CYP3A4
- alcohol, cocaine, tobacco smoking
Inhibition of CYP3A4
-Cannabinoids (marijuana), β-carbolines, alcohol |
-Decreased bioavailability of ART
- Toxicity from metabolites |
| Maraviroc |
3A4 |
| Cenicriviroc |
3A4, 2C8 (minor) |
| Integrase Inhibitors |
|
- Increased bioavailability of ART
- Toxicity from overdosing |
| Elvitegravir |
3A4 |
| Dolutegravir |
3A4 (minor) |
|
