Chronic hepatitis B
1. HBsAg-positive>6 months
2. Serum HBV DNA>20,000 IU/mL (105copies/mL). Lower values (2,000-20,000 IU/Ml) (104-105 copies/mL) are often seen in HBeAg-negative chronic hepatitis B
3. Persistent or intermittent elevation in ALT/AST levels
4. Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation |
Inactive HBsAg carrier state
1. HBsAg-positive>6 months
2. HBeAg-negative, anti-HBe+
3. Serum HBV DNA<2,000 IU/mL
4. Persistently normal ALT/AST levels
5. Liver biopsy confirming absence of significant hepatitis |
Resolved hepatitis B
1. Previous known history of acute or chronic hepatitis B or the presence of anti-HBc± anti-HBs
2. HBsAg -negative
3. Undetectable serum HBV DNA
4. Normal ALT levels |
