First authors of the studies Number of patients Patients with chronic hepatitis B Inactive HBsAg carriers Patients with resolved hepatitis B Patients with HBV reactivation     Proph + Proph- Proph + Proph-     Chung SJ et al. (44) 8 0 0 0 8 (1) 0 1 Charpin C et al. (45) 21 0 0 0 0 21 0 Caporali R et al. (46) 67 0 0 0 0 67 0 Kim YJ et al. (47) 96 1 7 (1) 0 0 88 (14) 15* Vassilopoulos D et al. (48) 33 6 (1) 0 8 0 19 1 Lan JL et al. (49) 88 10 8 (5) 0 0 70 (1) 6 Fotiadou C et al (50) 7 0 0 7 (1) 0 0 1 Tamori A et al. (51)‡ 44 2 0 0 0 42 0 Prignano F et al. (52) 11 0 0 0 0 11 0 Urata Y et al. (53) 135 0 0 0 0 135 (7**) 7 Cho YT et al. (54) 7 1 4 (2) 0 2 (1) 0 3 Laurenti R et al. (55) 8 0 0 1 0 7 0 Papa A et al. (34) 23 0 0 1 0 22 0 Biondo MI et al. (56) 20 0 0 0 0 20 0 Ye H et al. (57) 87 4 2 (2) 9 22 (6) 50 8 Footnotes : Proph±: antiviral prophylactic treatment administered or not, respectively; numbers in brackets () indicate cases of reactivation within the HBV state subgroups; * in this study reactivation was defined only by persistent increase of liver enzymes, without taking into account the other reactivation criteria (see Text); ‡ in this study three cases of reactivation were observed in patients treated with Methotrexate but not with anti-TNFα; ** in this study one case of reactivation was observed in patients treated with Methotrexate but not with anti-TNFα

Table 2: Prospective/retrospective studies on patients exposed to HBV and treated with anti-TNFα.

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