Drug in initial therapy Total started Observed number and % switched due to toxicity Median time to switch (days) D4T 2149 530 (24.6%) 141 AZT 1433 261 (18.2%) 81 TDF 2938 22 (0.7%) 58 NVP 4288 285 (6.6%) v EFV 3657 124 (3.4%) 119 LPV/r 622 13 (2%) 25

Table 2: Numbers and proportions of patients switching therapy due to toxicity; The nucleos(t)ides (D4T, AZT, TDF) were switched among each other, and the nonnucleosides (NVP, EFV) were switched to each other or to LPVr, as appropriate.

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