| Drug |
D4T |
AZT |
TDF |
NVP |
EFV |
| Toxicities |
(n = 2149) |
(n = 1433) |
(n = 2938) |
(n=4288) |
(n=3657) |
| Lactic acidosis/ |
| pancreatitis/ |
57 (2.7%) |
0 |
0 |
|
| lipoatrophy |
|
|
|
| Peripheral |
279 (13%) |
0 |
0 |
| Neuropathy |
|
| Headache/ GI |
0 |
6 (0.4%) |
0 |
| intolerance |
|
| Anemia |
0 |
123 (8.6%) |
0 |
| Renal toxicity |
0 |
0 |
3 (0.1%) |
| Other/ Reason not |
194 (9%) |
132 (9.2%) |
19 (0.6%) |
| Documented |
| Total switched due |
530 |
261 |
22 |
|
| to NRTI toxicity |
-24.60% |
-18.20% |
(0.7%)* |
| Hepatotoxicity |
|
18 (0.4%) |
2 (0.05%) |
| Rash |
92 (2.1%) |
18 (0.5%) |
| CNS |
0 |
20 (0.5%) |
| Other/Reason not |
175 |
84 |
| documented |
-4.10% |
-2.30% |
| Total switched due |
|
285 |
125 |
| to NNRTI toxicity |
|
(6.6%) |
(3.4%)* |
*p<0.001 |
