Par Description Value Source λ1 rate of creation of CD4+ from within the body 10(ml)−1 [21] b1 natural death rate of uninfected CD4+ 0.01 [20] q probability that HIV infects hepatocytes 0.2 Estimate p probability that at infection, hepatocyte becomes productively infected 0.3 Estimate µ rate at which latently infected hepatocytes become productive 0.006 Estimate β1 rate of transmission of HIV in CD4+ 0.00015(ml)−1 [21] x antigen-independent CTLs proliferation rate 20 [16] k2 antigen-dependent proliferation rate of CTLs 0.2 [24] α rate at which exposed CD4+ become uninfected 0.01 [17] π rate at which exposed CD4+ become infectious 0.23 [17] b2 death rate of infected CD4+ due to infection 0.5 [29] k1 rate at which CTLs kill infected CD4+ and hepatocytes 0.4 Estimate λ2 rate of creation of hepatocytes from within the body 100(ml)−1 Estimate b3 natural death rate of hepatocytes 0.002 [30] β2 rate of transmission of HIV in hepatocytes 0.000015(ml)−1 Estimate b4 death rate of hepatocytes due to infection 0.05 Estimate b5 rate of clearance of CTLS by all means 0.15 [18] s1 average rate of production of virions by an infected CD4+ 50,000 [31] s2 average rate of production of virions by an infected hepatocyte 1000 Estimate b6 death rate of HIV 2 [29] m rate of production of virions from macroghages 5 [16]

Table 1: Parameters values as used in the model of HIV infection in the liver while therapy is administered.

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