Formulation Code AUC (μg.hr/ml) Cmax (μg/ml) T1/2 (hr)
AZT 13.4 ± 0.3 3.17 ± 0.2 1.9 ± 0.1
AZT-dendrimer complex 21.7 ± 0.8 3.29 ± 0.3 7.21 ± 0.4
Data are represented as Mean ± SD (n=3)
Abbreviations: AUC, area under the concentration–time curve Cmax, peak plasma concentration; T1/2 biological half life
Table 3: Pharmacokinetic parameters of AZT after administration in free form and as AZT-dendrimer complex.
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