| 
   
  | Sides effects | % at 4
    Weeks n=68 | % at 12
    weeks n=61 | %at 24 weeks
    n=50 | p value
    (Fisher test) |  
  | Clinical 
 |  |  |  |  |  
  | Cutaneos | 5 | 2 | 0 | NS (p=0.21) |  
  | Neurological | 2 | 4 | 4 | NS (p=0.41) |  
  | Nausea/vomiting | 1 | 1 | 0 | NS (p=1) |  
  | Biogical |  |  |  |  |  
  | Transimasemia | 18 | 22 | 0 | (p=0.000) |  
  | Creatinine | 7 | 4 | 0 | NS (p=0.051) |  
  | Aneamia | 61 | 29 | 10 | p=0.000 |  
  | Metabolic | 24 | 6 | 1 | NS (p=0.36) |  |