| |
Total (n=428) |
Genotype 1 (n=192) |
Genotype 2 (n=29) |
Genotype 3 (n=130) |
Genotype 4 (n=63) |
Undefined (n=14) |
p values* |
p values** |
| Demographics |
| Male gender (%) |
245 (57.2) |
108 (56.3) |
16 (55.2) |
76 (58.5) |
36 (57.1) |
9 (64.3) |
0.974 |
0.901 |
| Age (years) |
44.8 ± 13.8 |
47.1 ± 13.1 |
53.3 ± 11.6 |
38.6 ± 13.1 |
47.1 ± 13.1 |
42.8 ± 16.2 |
<0.001 |
0.975 |
| Age >40 years old (%) |
241 (57.4) |
126 (66.3) |
23 (79.3) |
47 (36.7) |
41 (66.1) |
4 (36.4) |
<0.001 |
0.978 |
| Mode of transmission |
|
|
|
|
|
|
<0.001 |
0.092 |
| IVDU |
124 (29.0) |
44 (22.9) |
4 (13.8) |
62 (47.7) |
10 (15.9) |
4 (28.6) |
|
|
| Transfusion |
81 (18.9) |
36 (18.8) |
8 (27.6) |
18 (13.8) |
17 (27.0) |
2 (14.3) |
|
|
| Multiple sex partners |
15 (3.5) |
11 (5.7) |
0 (0) |
4 (3.1) |
0 (0) |
0 (0) |
|
|
| Unknown |
208 (48.6) |
101 (52.6) |
17 (58.6) |
46 (35.4) |
36 (57.1) |
8 (57.1) |
|
|
| Past alcohol abuse (%) |
49 (12.0) |
18 (9.5) |
1 (3.4) |
17 (13.8) |
11 (18.3) |
2 (33.3) |
0.078 |
0.062 |
| Somatometrics |
| BMI (kg/m2) |
23.30 ± 3.80 |
23.36 ± 3.92 |
25.29 ± 4.33 |
22.88 ± 3.59 |
23.03 ± 3.66 |
24.50 ± 2.12 |
0.423 |
0.695 |
| BMI (categorical) |
|
|
|
|
|
|
0.088 |
0.522 |
| Normal BMI |
144 (38.5) |
62 (34.8) |
9 (32.1) |
49 (43.4) |
23 (43.4) |
1 (50.0) |
|
|
| Overweight |
189 (50.5) |
90 (50.6) |
14 (50.0) |
61 (54.0) |
23 (43.4) |
1 (50.0) |
|
|
| Obese |
41 (11) |
26 (14.6) |
5 (17.9) |
3 (2.7) |
7 (13.2) |
0 (0) |
|
|
| Virology |
| High viral load (%) |
92 (44.9) |
34 (37.8) |
6 (42.9) |
36 (52.9) |
14 (48.3) |
2 (50.0) |
0.431 |
0.316 |
| ALT >ULN (%) |
378 (92.2) |
173 (95.1) |
24 (82.8) |
122 (94.6) |
51 (83.6) |
8 (88.9) |
0.011 |
0.064 |
| AST >ULN (%) |
340 (82.9) |
153 (84.1) |
22 (75.9) |
107 (82.9) |
50 (82.0) |
8 (88.9) |
0.835 |
0.702 |
| Histology |
| Severe inflammation (%) |
18 (4.7) |
11 (6.0) |
0 (0) |
3 (2.7) |
2 (3.9) |
2 (18.2) |
0.118 |
0.570 |
| Advanced fibrosis (%) |
58 (15.1) |
27 (14.5) |
4 (16.0) |
16 (14.5) |
10 (19.6) |
1 (9.1) |
0.877 |
0.375 |
| Hepatic steatosis |
133 (35.6) |
60 (33.5) |
16 (36.0) |
37 (33.9) |
21 (41.2) |
6 (60) |
0.439 |
0.313 |
| Treatment |
| Naïve (%) |
357 (87.7) |
159 (84.6) |
26 (89.7) |
116 (92.8) |
50 (84.7) |
6 (100) |
0.189 |
0.975 |
| Type of PegIFNα |
|
|
|
|
|
|
<0.001 |
0.712 |
| -2a |
123 (30.3) |
44 (23.2) |
15 (51.7) |
52 (40.9) |
11 (20.8) |
1 (14.3) |
|
|
| -2b |
283 (69.7) |
146 (76.8) |
14 (48.3) |
75 (59.1) |
42 (79.2) |
6 (85.7) |
|
|
| Adherence to dose (%) |
373 (87.1) |
160 (83.3) |
25 (86.2) |
120 (92.3) |
55 (87.3) |
13 (92.9) |
0.198 |
0.472 |
| SVR (%) |
283 (66.1) |
119 (62.0) |
22 (75.9) |
109 (83.8) |
25 (39.7) |
8 (57.1) |
<0.001 |
0.002 |
* for comparisons between 1,2,3,4 and undefined genotypes
** for comparisons between genotypes 1 and 4 |
