Figure 1 | Four known inhibitors of the interaction..

Figure 1: Four known inhibitors of the interaction between TNFα and TNFR1. Interaction with the proteins were tested through biotin or radio-labeled TNFα
a) Suramin, a natural product from, IC₅₀ = 35 μM (¹²⁵I or Eu- or biotin-labeled TNFα used in assay) [5,6];
b) WP9QY, peptidomimetic developed by Takasaki et al. [10], IC₅₀ = 5 μM (¹²⁵I-labeled TNFα used in assay) [10];
c) IW927, small molecule developed by Carter et al. [11], IC₅₀ = 50 nM (Eu-TNFα based assay) [11]; and
d) Saponin, a natural product [7].

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