Type of cancer Non-comparative studies   Type of non-comparative study Total number of
patients in noncomparative
studies  
Single arm
trial
Prospective
case series
Retrospective case
series
Case report
Anal [2-5] 4 0 2 1 1 19
Bile duct [6-17] 12 4 1 7 0 181
Bladder [23-29] 7 5 0 2 0 190
Brain [30-34] 5 3 0 2 0 292
Breast [36-40] 5 3 0 2 0 48
Cervical [44-49] 6 5 0 1 0 327
Esophageal - early [51-73] 23 0 14 9 0 413
Esophageal – advanced/inoperable
[62,76-83]
9 0 3 6 0 566
Eye [84-94] 11 1 1 6 3 97
Gastrointestinal [96-100] 5 3 1 1 0 96
Head and neck – nasopharyngeal [102] 1 0 0 0 1 1
Head and neck – oral and laryngeal
[103,104,261]
3 1 0 3 0 326
Head and neck – oral [108-116,262] 10 3 1 6 0 393
Head and neck – laryngeal [263,264] 2 2 0 0 0 34
Head and neck – oral and pharyngeal
[118-120]
3 0 0 3 0 27
Head and neck [121-128,265,266] 10 7 1 2 0 343
Intraperitonealcarcinomatosis and sarcomatosis [130,131] 2 2 0 0 0 122
Colorectal – metastatic (liver) [132,267] 2 2 0 0 0 31
Lung [142-159] 18 4 2 10 2 1154
Mesothelioma [162,163,268] 3 3 0 0 0 104
Ovarian [165] 1 1 0 0 0 8
Pancreatic [269] 1 0 0 1 0 16
Pituitary [167] 1 1 0 0 0 12
Prostate [168-173] 6 5 0 1 0   111
Sarcoma [174] 1 1 0 0 0 10
Skin – basal cell [191-213] 23 1 14 7 1 1302
Skin – Bowen’s [237,238] 2 0 1 0 1 15
Skin – multiple (non-melanoma) [214- 236] 23 3 9 11 0 1887*
Skin – cutaneous T-cell lymphoma
[243-249]
7 1 0 3 3 22
Skin – Kaposi’s sarcoma [241,242] 2     1 1 26
Skin – melanoma [239,240] 2 0 0 2 0 63
Skin – Paget’s disease, extramammary
[4,220,222,250-256]
10 1 2 4 3 52
Vulval [259,260] 2 1 1 0 0 31
Total 222 61 52 89 16 8319
*Number of patients not reported for one study (reported number of lesions instead)
Table 2: Number of non-comparative studies according to cancer type.
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