Brain Region |
ChAT activity |
ChAT mRNA |
ChAT protein |
NOS activity |
NOS protein |
NOS mRNA |
Frontal Cortex |
↓(*) |
Total:↔
M-ChAT:↔ |
ND |
↔ |
nNOS: ↔
eNOS:ND
iNOS:↔ |
nNOS:↔
eNOS:↓(*)
iNOS:ND |
| Hippocampus |
↓(+) |
Total:↔
M-ChAT:↔ |
variable |
↔ |
nNOS: ↔
eNOS:ND
iNOS:↔ |
nNOS:↔
eNOS:↓(*)
iNOS:ND |
| Nucleus basalis of Meynert |
↔ |
Total:↔
M-ChAT: ↓ |
variable |
↔ |
nNOS: ↔
eNOS:ND
iNOS:↔ |
nNOS:↔
eNOS:↓(*)
iNOS:ND |
| Caudate |
↔ |
Total:↔
M-ChAT:↔ |
↔ |
↔ |
nNOS: ↔
eNOS:ND
iNOS:↔ |
nNOS:↔
eNOS:↓(*)
iNOS:ND |
ChAT, choline acetyltransferase; NOS, nitric oxide synthase; n, neuronal; e, endothelial; I, inducible; ↓, decrease; (*), statistically significant difference; (+), difference approached
statistical significance; ↔, no change compared to control tissue; ND, not detected in most/all samples |
