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Figure 2: Distribution of MHC II-IR microglia (brown cells) within the hippocampus counterstained with cresyl violet (A) at 10 X and 20 X (insert). Scale bar = 200 μm. Number of MHC II-IR cells was counted per area (B). LPS infusion lead to an increased in the density of MHC II-IR microglia in hippocampal subregion; CA3>CA1 of LPS 2w (p=0.041) and CA3>DG>CA1 in LPS 4w and LPS 8w (p ≤ 0.022). Within the DG and CA3, LPS 4w and LPS 8w had significantly more MHC II-IR microglia than aCSF controls and LPS 2w (p ≤ 0.001*†). In the CA3, LPS 8w rats had significantly more MHC II-IR microglia than LPS 4w rats (p=0.029).
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