Authors Year Reference Methods Number of subjects AD Control Crapper et al. 1973 [16] EAAS 5 3 Crapper et al. 1976 [17] EAAS 10 7 Trapp et al. 1978 [97] EAAS 4 4 Crapper et al. 1980 [18] EAAS 18 17 Perl and Brody 1980 [98] EDX 3 3 Traub et al. 1981 [99] EAAS 7 26 Markesbery et al. 1981 [69] NAA 12 28 Ward and Mason 1987 [100] NAA 28 30 Lukiw et al. 1992 [101] EAAS 21 17 Xu et al. 1992 [102] EAAS 10 10 Corrigan et al. 1993 [103] ICP-MS 12 12 Lovell et al. 1993 [104] LMMS 7 5 Andrasi et al. 1995 [105] ICP-AES, INAA 9 20 Bouras et al. 1997 [106] LMMS 4 3 Solomon et al. 2001 [107] IF-CLM 5 5 Srivastava and Jain 2002 [108] ICP-MS 4 4 Andrási et al. 2005 [109] ICP-AES, INAA 3 3 Walton 2006 [110] HS 6 6 Walton 2010 [111] HS 5 5 Rushina et al. 2011 [112] EAAS 29 27 EAAS: electrothermal atomic absorption spectrometry; EDX: energy-dispersive X-ray spectroscopy; NAA: neutron activation analysis; ICP-MS: inductively coupled plasma source mass spectrometry; LMMS: laser microprobe mass spectrometry; ICP-AES: inductively coupled plasma atomic emission spectrometry; INAA: instrumental neutron activation analysis; IF-CLM: immunofluorescence using confocal laser microscopy; HS: histological staining.

Table 1: Reports of increased levels of Aluminum (Al) in Alzheimer’s disease (AD) brains.

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