Authors Year Reference Methods Number of subjects Al detection
AD control
Masters et al. 1985 [130] EDX 6 - +
Candy et al. 1986 [138] EDX, SIMS 7 - +
Jacobs et al. 1989 [113] EDX 7 4 -
Larsson et al. 1990 [139] Proton microprobe 2 - -
Moretz et al. 1990 [132] EDX 3 - -
Senitz and Blüthner 1990 [140] Morin staining 3 - +
Chafi et al. 1991 [133] WDX, SIMS 7 - -
Landsberg et al. 1992 [141] Proton (nuclear) microscopy 5 2 -
Landsberg et al. 1993 [142] Proton (nuclear) microscopy 6 2 ±
Kasa et al. 1995 [135] solachrone azurine 10 5 ±
Yumoto et al. 2009 [143] TEM-EDX 5 - +
EDX: energy-dispersive X-ray spectroscopy; WDX: wavelength-dispersive X-ray microanalysis; SIMS: secondary ion mass spectrometry; TEM-EDX: energydispersive X-ray spectroscopy combined with transmission electron microscopy.
Table 6: Detection of Al in senile plaques of AD brain tissues.
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