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Figure 2: Scheme of the progression pathways and stages of Lewy body (LB) disorders. The pathway for Parkinson’s disease (PD) is suggested to proceed through stage IIa (brain stem predominant) and that for dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) with LBs probably pass through stage IIb. For incidental LB disease (iLBD), both pathways seem possible, whereas only PD/PD dementia (PDD), DLB, and the LB variant of AD (LBV/ AD) progress to the neocortical stage. Modified with permission from [142]. |