Levels of AD neuropathologic changes
"A" Thal Phase for Aβ plaques "B" Braak and Braak NFT stage "C" CERAD score
0 0 0 None 0 None (neg.)
1 1 or 2 1 I              or II 1 Sparse (A)
2 3 2 III           or IV 2 Moderate (B)
3 4 or 5 3 V             or VI 3 Frequent (C)
AD neuropathologic change B
A C 0 or 1 2 3
0 0 Nota Nota Nota
1 0 or 1 Low Low Lowb
2 or 3f Low Intermediate Intermediatee
2 Any C Lowc Intermediate Intermediatee
3 0 or 1 Lowc Intermediate Intermediatee
2 or 3 Lowc Intermediate High
a High levels of neuritic plaques and low Thal Aβ phase are rare and should prompt reconsideration
b Widespread NFTs with some Aβ plaques but limited neuritic plaques are infrequent
c High levels of Aβ or neuritic plaques with low Braak stage should prompt consideration of co-morbidity, eg, CVLs, etc.
Table 1: "ABC" score for AD neuropathological changes. Modified with premission from [100].
Goto home»