Study Aim of Comparison HVLT total recall performance
AUC Optimal Cut-off Sensitivity Specificity
 (95% CI)
Brandt et al. [6] NCI vs Amnesic & Dementia   19/20 0.94 1
Frank et al. [9] NCI VS mild Dementia - 18 0.96 0.8
Hogervorst  et al. [8] NCI VS Dementia 0.97 14.5 0.87 0.98
(0.95-0.99) 19.5 0.95 0.77
De Jager et al. [10] NCI VS MCI VS AD VS CVD 0.88 15.5 (MCI VS AD) 0.91 0.69
0.84 14.5 (CVD VS AD) 0.82 0.75
Kuslansky et al. [12] NCI VS Dementia 0.89 <16 0.83 0.83
Schrijnemaekers et al. [11] NCI VS MCI VS AD   24.5 (NCI VS MCI) 0.82 0.79
16.5 (MCI VS AD) 0.79 0.96
De Jager et al. [13] NCI VS MCI 0.9 25.5 0.79 0.95
Shi et al. [14] NCI VS MCI VS Dementia 0.98 15.5 (NCI vs Dementia) 0.95 0.93
0.79 21.5 (NCI vs MCI) 0.69 0.71
Gonza´lez-Palau et al. [15] NCI VS AD 0.95 13 0.96 0.85
(0.92-0.98)
0.77 12.5 (AD VS HD) 0.97 0.52
(0.65-0.89)
Aretouli et al. [16] AD VS HD VS PD 0.64 12.5 (AD VS PD) 0.72 0.52
(0.48-0.80)
0.66 13.5 (PD VS HD) 0.87 0.44
(0.49-0.83)
Table 2: The discriminate ability of the HVLT in differentiating between diagnostic groups in the reviewed studies which reported AUC and optimal cut-off scores Notes: NCI=No Cognitive Impairment; MCI=Mild Cognitive Impairment; AD=Alzheimer’ Disease; CVD= Cerebral Vascular Disease; HD= Huntington’s disease; PD=Parkinson’s disease.
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