RISK FACTOR POPULATION PREVALENCE RELATIVE RISK (95% CI) PAR% (confidence range) NO. OF CASES ATTRIBUTABLE (thousands; confidence range)
Worldwide
Diabetes mellitus 6·4% 1·39 (1·17–1·66) 2·4% (1·1–4·1) 826 (365–1374)
Midlife hypertension 8·9% 1·61 (1·16–2·24) 5·1% (1·4–9·9) 1746 (476–3369)
Midlife obesity 3·4% 1·60 (1·34–1·92) 2·0% (1·1–3·0) 678 (387–1028)
Depression 13·2% 1·90 (1·55–2·33) 10·6% (6·8–14·9) 3600 (2295–5063)
Physical inactivity 17·7% 1·82 (1·19–2·78) 12·7% (3·3–24·0) 4297 (1103–8122)
Smoking 27·4% 1·59 (1·15–2·20) 13·9% (3·9–24·7) 4718 (1338–8388)
Low education 40·0% 1·59 (1·35–1·86) 19·1% (12·3–25·6) 6473 (4163–8677)
Combined (maximum) .. .. 50·7% 17187 28*
USA
Diabetes mellitus 8·7% 1·39 (1·17–1·66) 3·3% (1·5–5·4) 174 (77–288)
Midlife hypertension 14·3% 1·61 (1·16–2·24) 8·0% (2·2–15·1) 425 (119–798)
Midlife obesity 13·1% 1·60 (1·34–1·92) 7·3% (4·3–10·8) 386 (226–570)
Depression 19·2% 1·90 (1·55–2·33) 14·7% (9·6–20·3) 781 (506–1078)
Physical inactivity 32·5% 1·82 (1·19–2·78) 21·0% (5·8–36·6) 1115 (308–1942)
Smoking 20·6% 1·59 (1·15–2·20) 10·8% (3·0–19·8) 574 (159–1050)
Low education 13·3% 1·59 (1·35–1·86) 7·3% (4·4–10·3) 386 (236–544)
Combined (maximum) .. .. 54·1% 2 866 951*
Table 2: Alzheimer's disease cases attributable to potentially modifiable risk factors worldwide and in the USA.
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