Substrate |
Physiological function |
Ub. |
Degradation |
Ref |
Hsp70 |
Molecular chaperone |
Mono |
No |
[16] |
α-Sp22 |
Lewy body component |
Poly |
Yes |
[17] |
Synphilin-1 |
Interact with α-synuclein |
Poly |
No |
[21] |
PICK1 |
Synaptic scaffolding protein |
Mono |
No |
[27] |
Ataxin-3 |
Polyglutamine |
Poly |
Yes |
[29] |
Ataxin-2 |
Polyglutamine |
Poly |
Yes |
[28] |
CDCrel-1 |
Synaptic vesicle associated GTPase |
Poly |
Yes |
[18] |
CDCrel-2a |
Synaptic vesicle associated GTPase |
Poly |
Yes |
[30] |
SynaptotagminXI |
Membrane trafficking protein |
Poly |
Yes |
[37] |
p38 |
Aminoacyl t-RNA synthetase cofactor |
Poly |
Yes |
[36] |
FBP1 |
Regulates c-myc mRNA |
Yes |
Yes |
[38] |
Cyclin E |
Cell cycle regulating protein |
Poly |
Yes |
[41] |
β-catenin |
Component in Wnt signaling |
Unknown |
Yes |
[44] |
RanBP2 |
Interact with nuclear pore complex |
Poly |
Yes |
[45] |
PDCD2-1 |
Involved in apoptosis, inflammation and proliferation |
Poly |
Yes |
[46] |
α/β-tubulin |
Cytoskeletal components |
Unknown |
Yes |
[48] |
Lim Kinase 1 |
Phosphorylates cofilin |
Poly |
Yes |
[51] |
Iκκγ |
Component in NFκB signaling |
Poly |
No |
[52] |
TRAF2 |
Component in NFκB signaling |
Yes |
No |
[52] |
Pael-R |
G-protein coupled receptor |
Poly |
Yes |
[54] |
PLCγ1 |
Hydrolyzes lipids |
Unknown |
Yes |
[57] |
Eps15 |
Internalizes EGF-R |
Mono |
No |
[60] |
VDAC |
Mitochondrial ion channel |
Poly |
No |
[63] |
Bcl-2 |
Anti-apoptotic protein |
Mono |
No |
[15] |
Mitofusin-1/-2 |
Mitochondrial fusion protein |
Poly |
Yes |
[70] |
Drp1 |
Mitochondrial fission protein |
Poly |
Yes |
[71] |
Miro |
Mitochondrial anchor protein |
Unknown |
Yes |
[72] |
