Substrate

Physiological function

Ub.

Degradation

Ref

Hsp70

Molecular chaperone

Mono

No

[16]

α-Sp22

Lewy body component

Poly

Yes

[17]

Synphilin-1

Interact with α-synuclein

Poly

No

[21]

PICK1

Synaptic scaffolding protein

Mono

No

[27]

Ataxin-3

Polyglutamine

Poly

Yes

[29]

Ataxin-2

Polyglutamine

Poly

Yes

[28]

CDCrel-1

Synaptic vesicle associated GTPase

Poly

Yes

[18]

CDCrel-2a

Synaptic vesicle associated GTPase

Poly

Yes

[30]

SynaptotagminXI

Membrane trafficking protein

Poly

Yes

[37]

p38

Aminoacyl t-RNA synthetase cofactor

Poly

Yes

[36]

FBP1

Regulates c-myc mRNA

Yes

Yes

[38]

Cyclin E

Cell cycle regulating protein

Poly

Yes

[41]

β-catenin

Component in Wnt signaling

Unknown

Yes

[44]

RanBP2

Interact with nuclear pore complex

Poly

Yes

[45]

PDCD2-1

Involved in apoptosis, inflammation and proliferation

Poly

Yes

[46]

α/β-tubulin

Cytoskeletal components

Unknown

Yes

[48]

Lim Kinase 1

Phosphorylates cofilin

Poly

Yes

[51]

Iκκγ

Component in NFκB signaling

Poly

No

[52]

TRAF2

Component in NFκB signaling

Yes

No

[52]

Pael-R

G-protein coupled receptor

Poly

Yes

[54]

PLCγ1

Hydrolyzes lipids

Unknown

Yes

[57]

Eps15

Internalizes EGF-R

Mono

No

[60]

VDAC

Mitochondrial ion channel

Poly

No

[63]

Bcl-2

Anti-apoptotic protein

Mono

No

[15]

Mitofusin-1/-2

Mitochondrial fusion protein

Poly

Yes

[70]

Drp1

Mitochondrial fission protein

Poly

Yes

[71]

Miro

Mitochondrial anchor protein

Unknown

Yes

[72]

Table 1: Parkin substrates (Ub: ubiquitylation by parkin).
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