| Protein |
Associated
Neurodegenerative disease |
Benefit from
Hsp70
elevation in vitro? |
Benefit from
Hsp70
elevation in vivo? |
Benefit from
Hsp90
inhibition in vitro? |
Benefit from
Hsp90
inhibition in vivo? |
| Tau |
Tauopathies (AD, CBD, PSP, FTDP-17) |
Yes [61] |
Yes [61] |
Yes [62,90] |
Yes [62,90] |
| α-synuclein |
PD, DLB, MSA |
Yes [220] |
? |
Yes[127,221] |
Yes [140] |
| LRRK2 |
PD |
Yes [138] |
? |
Yes [139] |
? |
| SOD1 |
ALS |
Yes [172-174] |
No [176] |
Yes [175] |
? |
| TDP-43 |
ALS/FTD |
Yes [222] |
Yes [194] |
Yes [223] |
Yes [193] |
| Huntingtin |
HD |
Yes [211] |
No [212] |
Yes [83] |
Yes [212] |
| Androgen receptor |
SBMA |
Yes [106,206] |
Yes [210,224] |
Yes[207,209] |
Yes
[207,208] |
| Ataxins |
SCA |
Yes [196] |
Yes [197,198] |
? |
? |
|
