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| Figure 8: A schematic view of the thyroid hormone regulatory network and thyroid disruption endpoints. Cytoplasmic T3BP: Cytoplasmic T3-binding protein;DIO1,2,3: deiodinases type1, 2, 3; NIS: sodiumiodidesymporter; Plasma THBPs: plasmathyroid hormone-binding proteins; rT3: reverse-T3 (inactive);SULT: sulfotransferase; T4- Gluc: T4 glucuronide (inactive); T4-Sulf: T4-Sulfate(inactive); TPO: thyroperoxidase; Tpt: membrane transporter; TR: thyroid hormone receptor; TSH: thyrotropin; UGT, glucuronosyltransferase; ( ) thyroid disruption endpoints.(Adopted from Line Jugan et al., 2010). |
