naloxone 6βNTX
Dose 0.05 mg 0.0 mg 0.05 mg 0.15 mg 0.5 mg 1.0 mg
Withdrawal Scales
OOWS (total)
2.5 ± 0.6 0.7 ± 0.6 0.8 ± 0.5 1.5 ± 0.6 3.5 ± 1.3 5.3 ± 4.0*
SOWS (total) 3.0 ± 2.8 1.3 ± 1.5 0.8 ± 1.0 1.3 ± 1.9 4.3 ± 2.2 4.3 ± 2.8
VAS
Any Drug Effect
15.4 ± 23.7 2.0 ± 1.7 0.5 ± 1.0 1.5 ± 1.7 34.3 ± 15.7* 24.0 ± 21.7*
Bad Drug Effect 13.5 ± 25.0 1.3 ± 1.2 0.8 ± 1.5 17.9 ± 32.5 42.5 ± 23.7 26.9 ± 33.0
Good Drug Effect 10.4 ± 18.9 1.3 ± 1.2 0.3 ± 0.5 2.2 ± 2.8 6.5 ± 12.3 1.0 ± 0.0
Opioid Withdrawal 5.6 ± 8.2 1.7 ± 1.5 1.3 ± 2.5 1.4 ± 1.3 21.0 ± 29.7 13.1 ± 8.1
Sickness 4.6 ± 6.5 0.7 ± 0.6 0.50 ± 1.00 9.3 ± 17.2 15.8 ± 18.1 9.0 ± 5.6
Vital Signs
Systolic BP (mmHg)
114.0 ± 1.8 121.7 ± 2.9 121.3 ± 7.0 118.5 ± 10.0 118.8 ± 7.6 134.7 ± 26.4
Diastolic BP (mmHg) 76.5 ± 3.8 83.7 ± 4.9 83.0 ± 5.9 76.5 ± 5.1 80.3 ± 5.7 88.3 ± 12.7
Heart Rate (bpm) 63.5 ± 8.0 65.0 ± 4.4 61.8 ± 6.2 59.5 ± 2.9 61.8 ± 5.7 71.7 ± 4.9
mean ± standard deviation; *p <.05 vs. placebo
Table 2: Peak values on withdrawal scales, VAS items, and vital signs.
Goto home»