Unstandardized Parameter Estimate (95% CI)
  Outcome Variables (Unadjusted) Outcome Variables (Adjusted)
Predictor Variables BDI-II Depressiona HAM-D Depressiona Proportion Illicit Drug Use Days BDI-II Depressiona HAM-D Depressiona Proportion Illicit Drug Use Days
Intercept 2.15 (1.82, 2. 47) 1.90 (1.63, 2.18) 0.27 (0.16, 0.38) 2.11 (1.79, 2.43) 1.88 (1.60, 2.15) 0.16 (-0.02, 0.34)b
0.03 (-0.15, 0.21)c
Linear Slope Baseline -6 months -0.01 (-0.15, 0.13) 0.02 (-0.09, 0.14) -0.004 (-0.05, 0.04) -0.02 (-0.15, 0.10) 0.01 (-0.09, 0.12) -0.003 (-0.05, 0.04)b -0.01 (-0.05, 0.04)c
Baseline Treatment Difference 0.27 (-0.20, 0.74) 0.34* (-0.06, 0.75) -0.13 (-0.29, 0.04) 0.16 (-0.31, 0.63) 0.27(-0.13, 0.67) -0.14* (-0.30, 0.02)b -0.17* (-0.33, -0.02)c
Treatment Difference in Linear Slope Baseline–6 months -0.12 (-0.32, 0.09) -0.09 (-0.26, 0.08) 0.01 (-0.06, 0.08) -0.12 (-0.31 0.07) -0.09 (-0.25, 0.06) 0.02 (-0.05, 0.09)b
0.02 (-0.05, 0.09)c
Note: Adjusted parameter estimates control for time-varying antidepressant use for BDI-II and HAM-D outcomes, and for time-varying BDI-IIb and HAM-Dc for the illicit drug use outcome. a log transformed. * p<0.10
Table 3: Random Effects Regression Results for Repeated Primary Outcome Measures.
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