| Reinforcer |
Animals |
Treatment |
Reinstatement Stimuli |
Effect |
Reference |
| Cocaine (SA) |
Male, SD |
Intra-PVT administration
CART 55-102 (0.625µg and 2.5µg) |
Cocaine Prime (10mg/kg) |
2.5µg dose significantly attenuated reinstatement |
James et al. (2010) + |
| Cocaine (SA) |
Male, SD rat |
SB-334867 (10, 20, 30mg/kg; i.p.)
4PT (10, 30mg/kg; i.p.) |
Tone + cue lights paired with cocaine infusions |
SB-334867: Dose-dependent decrease in reinstatement.
4PT: No effect on reinstatement |
Smith et al. (2009) |
| Cocaine (SA) |
Male, SD, rat |
SB-334867 (10, 20, 30mg/kg; i.p.) |
Re-exposure to SA environment following abstinence
Context (visual, auditory, olfactory and tactile cues) |
Dose-dependently decreased reinstatement following abstinence and context-induced reinstatement |
Smith et al. (2010) |
| Cocaine (SA) |
Male, SD rat |
Intra-VTA SB-334867 (1µg and 3µg/0.5µl, unilaterally) |
S+ (Background white noise) |
Decreased reinstatement (3µg) |
James et al. (2010) |
| Cocaine (SA) |
Male, Wistar rat |
1. SB-334867 (15, 30mg/kg; i.p.)
2. Orexin-A
(0.3, 0.75, 1.5nmol; i.c.v.) |
•Footshock (15mins, 0.5mA, variable interval 40s)
•None
|
•Dose-dependent decrease in reinstatement
•0.75 and 1.5nmol doses induced reinstatement (dose-dependently)
|
Boutrel et al. (2005) |
| Cocaine (SA) |
Male, LE rat |
1. Intra-VTA Hcrt-1 and Hcrt-2 (10µm)
2. Intra-VTA SB-408124 |
1. None
2. Footshock (20mins, 0.4-0.6mA, variable interval 40 + 30s) |
1. Hcrt-1: induced reinstatement. Hcrt-2: No effect
2. No effect |
Wang et al. (2009) |
+ Only one other study has investigated the functional role of CART on reinstatement behaviour. King et al. (2010) showed that i.c.v. administration of CART 55-102
(0.625μg and 1.25μg), but not CART 1-27 (1.25μg), dose-dependently decreased reinstatement alcoholic beer-seeking in a renewal model.
* SA: Self-administration, SB-334867 and SB-408124 are selective OXR1 antagonists. 4PT is a selective OXR2 antagonist. |
