BICOMBO STEAL
  ABC/3TC TDF/FTC ABC/3TC TDF/FTC
  n=167 n=166 n=178 n=179
  n % n % n % n %
Deaths 0 - 2 1.2 2 1.1 2 1.1
AIDS events 1 0.6 0 - 0 - 0 -
Serious non-AIDS                
Cardio vascular 2 1.2 1 0.6 8 4.5 1 0.6
Study RD [%(95% CI] 0.6 (-1.4,2.6) 3.9 (0.7, 7.1)
RD[% (95%CI)] 2.1 (-1.6, 5.7)p=0.267, heterogeneity  I272.9 p=0.055
Cancer 6 3.6 4 2.4 5 2.8 2 1.1
Study RD [%(95% CI] 1.2(-2.5, 4.8) 1.7 (-1.2, 4.5)
RD[% (95%CI)] 1.5 (-0.8, 3.7) p=0.197, heterogeneity I20.0% p=0.834
Fracture 3 1.8 2 1.2 0 0.0 1 0.6
Renal disease 0 0.0 1 0.6 0 0.0 0 0.0
Liver disease 0 0.0 0 0.0 1 0.6 0 0.0
Total 11 6.6 8 4.8 14 7.9 4 2.2
Study RD [% (95%CI)] 1.8 (-3.2, 6.7)   5.6 (1.1, 10.1)  
RD[% (95%CI)] 3.8 (0.1, 7.6) p=0.044, heterogeneity I2=19.5% p=0.265
*Only grade 3/4 adverse events that resulted in treatment cessation
RD= Difference in proportions, (ABC+3TC) minus (TDF+FTC)
Table 2: Serious non -AIDS events by randomised arm and trial.
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