Sample code PI mutations NNRTI mutations NRTI mutations
Plasma vRNA PBMC DNA Plasma vRNA PBMC DNA Plasma vRNA PBMC DNA
TC002a Wild type Wild type Wild type Wild type Wild type Wild type
TC106a L90M Wild type Wild type Wild type M184V  M184MV
TC006b Wild type Wild type Wild type Wild type Wild type Wild type
TC050b Wild type Wild type Wild type Wild type Wild type L74V, M184V
TC008c Wild type Wild type Wild type Wild type M184V M184V
TC118c Wild type Wild type K103KR, M230LM K103R, V179D, M230L L74LV, M184V  M184V
TC215c Wild type Wild type K103R, V179D, M230L K103R, V108I, V179D, M230L M184V, T215F M184V, T215F
TC045d Wild type Wild type Y181C, G190A  Y181C, G190AG M41L, D67N, K70R, Q151M, M184V, T215FY, K219E  M41LM, D67DN, K70R, M184MV, T215Y, K219EK
TC201d I154F Wild type Y181C, G190A V108IV, Y181C, G190A M41L, A62V, K65R, K70R, V75T, Q151M, T215Y, K219E M41L, K65R, K70R, V75IM, Q151M, M184MV, T215Y, K219E
TC012 Wild type Wild type Wild type K238KQ Wild type Wild type
TC013 Wild type Wild type Wild type Wild type Wild type Wild type
TC041 Wild type Wild type K103R, Y181CY K103RT, Y181CY A62AV, K65R, K219KQ L74LV, V75AV, Y115FY, M184MV
TC045d Wild type Wild type Y181C, G190A  Y181C, G190AG M41L, D67N, K70R, Q151M, M184V, T215FY, K219E  M41LM, D67DN, K70R, M184MV, T215Y, K219EK
TC049 V32VG, M46MI, I47IM, L76V M46I, L76V, L10I K103N, Y181C, G190A K103N, Y181C, G190A M41L, D67N, T69i, L74V, T215Y M41L, D67N, L74V, T215Y
TC052 Wild type Wild type G190A G190A, Y188H  M184V M184V
TC056 L90M, A71V, G73S L90M, A71V, G73S Y181C Y181C D67N, T69N, K70R, M184V, T215V, K219Q D67N, T69N, K70R, M184V, T215V, K219Q
TC059 Wild type Wild type K103N, Y188*FLY K103KN, Y188*FLY, P225HP Wild type Wild type
TC060 I54IV, V82A, A71AT V82A K101E, V106M, V108IV K101E, V106M, Y181C  K65R  K65R
TC070 L90M L90M Wild type Wild type D67G, T69i, K70R, K219Q  D67G, T69i, K70R, K219Q
TC109 A71T A71T K103KN, V106MV, Y181CY K103N, Y181CY Q151KLMQ Q151KLMQ
TC110 G48V, I54T, V82A, L10I, A71V G48GV, I54IT, V82VA, L10LI, A71AV Wild type Wild type A62V, K65R, F116Y, Q151M, M184V A62AV, K65KR, F116FY, Q151KLMQ, M184MV
TC111 Wild type Wild type P236LP Wild type T215PT Wild type
TC113 Wild type Wild type Wild type Wild type Wild type Wild type
TC114e Wild type Wild type Wild type Wild type Wild type Wild type
TC117f Wild type` Wild type Wild type Wild type Wild type Wild type
TC118c Wild type Wild type K103KR, M230LM  K103R, V179D, M230L  L74LV, M184V  M184V
TC200e Wild type Wild type Wild type Wild type  V75GV Wild type
TC203 Wild type Wild type Wild type Wild type M184MV M184V
TC204 A71T A71T K103N, Y181C  K103N, Y181C F116Y, Q151M, M184V K65R, Q151M
TC206 Wild type Wild type Wild type Wild type Wild type Wild type
TC215c Wild type Wild type K103R, V179D, M230L K103R, V108I, V179D, M230L M184V, T215F M184V, T215F
TC216 M46I, I84V, L90M, A71V, G73S L90M, A71V, G73S K101E, Y181C, G190A K101E, Y181C, G190A D67N, T69N, K70R, T215F, K219Q D67N, T69N, K70R, M184V, T215F, K219Q
TC238 Wild type Wild type K103N K103N M41L, M184V, T215Y M41L, M184V, T215Y
TC242f Wild type Wild type Wild type Wild type Wild type Wild type
PI, protease inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; vRNA, viral RNA; PBMC, peripheral blood mononuclear cell; N/A, not available a-f Samples with the superscripted letters are from a same patient in different time points.
* Unique mutations comparing RNA and DNA from the same patient sample are bolded.
Table 2: PI, NNRTI and NRTI drug-resistant mutations.
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