Carotid IMT ≥ 0.8 vs OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value  

All participants      

Adjustments Unadjusted Age- and sex Age-, sex- and conventional risk factors*
CLI in patients HIV- 6.34 (4.18-9.61) <0.0001 2.89 (1.79-4.66) < 0.0001 2.70 (1.51-4.81) < 0.0001   
HIV+ 7.52 (3.24-17.44) <0.0001 7.69 (2.92-20.25) < 0.0001 8.89 (2.79-28.32) < 0.0001

HIV negative patients with CLI<60 years old

Adjustments Unadjusted  Age-, and sex- Age-, sex-, and conventional risk factors*
CLI in patients HIV- 5.95 (3.33-10.63) <0.0001 5.16 (2.64-10.09) < 0.0001 4.77 (1.91-11.88) < 0.0001

Men

Adjustments Unadjusted Age- Age-, and conventional risk factors*
CLI in patients HIV- 4.82 (2.72-8.57) <0.0001 2.73 (1.46-5.13) < 0.005 1.88 (0.80-4.46) = 0.15          
HIV+ 6.86 (2.59-18.15) =0.0001 8.34 (2.81-24.76) < 0.0001 8.83 (2.10-37.21) = 0.001

Smokers

Adjustments

Unadjusted

Age, and sex-

Age-, sex- and conventional risk factor (except smoking)*   
CLI in patients HIV- 10.12 (3.82-26.82) <0.0001 6.69 (2.25-19.92) <0.0005 5.03 (1.61-15.74) <0.01 
HIV+ 14.00 (3.89-50.39) <0.0001 8.77 (2.15-35.72) <0.0005 11.29 (1.74-73.10) <0.01

Black African

Adjustments Unadjusted Age, and sex- Age-, sex- and conventional risk factors*
CLI in patients HIV- 6.47 (4.01-10.44) <0.0001 2.69 (1.56-4.66) <0.001 2.96 (1.45-6.04) <0.005         
HIV+ 7.47 (3.12-17.87) <0.0001 9.00 (3.32-24.40) <0.0001 9.90 (3.01-32.60) <0.0001
OR- Odds Ratio; CI- Confidence Interval. See Table 4 for sample sizes in subgroups. *Additional adjustments are for hypertension, diabetes mellitus, smoking, triglyceride concentrations and HDL cholesterol concentrations. Probability values were further adjusted for non-independence of family members.
Table 5: Relationship between an increased carotid intima-media thickness (IMT≥0.8 mm) with critical limb ischemia (CLI) in patients with (+) (n=25) or without (-) (n=192) a human immunodeficiency virus (HIV) infection as compared to a community sample (n=430).
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