| 
      
      * P-value obtained by backward stepwise regression
        |  |  |  | Bivariate analysis | Multivariate analysis, n =793 |  
        |  | Occurrence | Cox |  | Fine-Gray |  | Cox |  | Fine-Gray |  |  
        | Characteristics | n =1136 | % | HR$crude[80%    CI] | P | SHR¶crude[80%    CI] | P | HRajusted[95% CI] | P * | SHRajusted[95%    CI] | P * |  
        | Age at Ti **(year)  |  |  |  | 0.0048 |  | 0.0013 |  | 0.0264 |  | 0.0058 |  
        | [18 – 50] | 210 | 21.81 | 1(Reference)  |  | 1(Reference)  |  | 1(Reference) |  | 1(Reference)  |  |  
        | [50 – 82] |   55 | 31.79 | 1.53 [1.26–1.86] |  | 1.61 [1.33–1.95] |  | 1.47 [1.04–2.07] |  | 1.60 [1.14–2.25] |  |  
        | Therapeutic education  |  |  |  | <0.0001 |  | <0.0001 |  | 0.0241 |  | 0.0341 |  
        | No | 202 | 22.20 | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  |  
        | Yes  |   63 | 27.88 | 1.77 [1.47–2.14] |  | 1.57 [1.30–1.90] |  | 1.43 [1.04–1.97] |  | 1.39 [1.02–1.89] |  |  
        | AIDS-defining    illness  | N=1092 | 100% |  | 0.0006 |  | 0.0129 |  | 0.0511 |  | 0.1605 |  
        | No | 209 | 22.21 | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  |  
        | Yes  |   47 | 31.13 | 1.74 [1.41–2.14] |  | 1.50 [1.21–1.86] |  | 1.45 [0.99–2.10] |  | 1.31 [0.89–1.92] |  |  
        | VL (log10 copie/mm3) Ti **  | N=829 | 100% |  | 0.0216 |  | 0.0173 |  | 0.0392 |  | 0.0308 |  
        | [1.7– 4.0] |   32 | 16.75 | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  | 1(Reference)  |  |  
        | [4.0– 5.0] |   86 | 26.71 | 1.74 [1.33–2.27] |  | 1.75 [1.35–2.28] |  | 1.71 [1.12–2.60] |  | 1.73 [1.15–2.60] |  |  
        | ≥ 5.0 |   79 | 25.00 | 1.66 [1.26–2.17] |  | 1.66 [1.27–2.17] |  | 1.41 [0.91–2.18]  |  | 1.48 [0.97–2.26]  |  |  ** Ti : Time of HAART initiation
 $ Hazard Ratio obtained by Cox model
 ¶ Subdistribution Hazards Ratio obtained by Fine-Gray model
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