Variable Sub-Cohort Mean ± SD (n = 58) Parameter Estimate Standard Error T-value P-value
HIV viral load (copies/mL)A 29,058±137,990 -0.918 0.385 -2.39 0.022*
CD4 cell count (cells/uL)A 557 ± 355 1.236 2.467 0.50 0.619
Oxidized glutathione(%) 26.49 ± 10.43 10.021 4.156 2.41 0.028*
MDA (uM) 0.54 ± 0.25 0.030 0.087 0.34 0.736
Mitochondrial 8-oxo-dG (ΔCt) 0.44 ± 0.53 -0.478 0.201 -2.38 0.028*
Complex I enzyme activity (%) 46.85 ± 16.36 -0.216 7.593 -0.03 0.978
Complex IV enzyme activity (%) 21.96 ± 14.65 -4.946 4.093 -1.21 0.246
Apoptosis (CK18 Average value (pM)B 130.49 ± 80.47 -67.489 22.453 -3.01 0.009*
*Indicates statistically significant results. P-value associated with linear regression analysis. Participants with BMI>28 kg/m2 excluded from regression analysis.
A No exclusion of participants with BMI>28 in this analysis.
B Participants who consume alcohol excluded.
Table 4: Effects ofthe Functional (Non-Null) GSTM1 Genotype on HIV Disease Progression and Oxidative Stress in HIV/HCV Co-Infected Sub-Cohort.
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