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| Figure 2: Mean ± SEM values for acetylcholine- or sodium nitroprussideinduced relaxations of subcutaneous vessels from control (broken lines and open circles) or HIV infected (continuous lines and solids circles) women preconstricted with norepinephrine (10-5 mol·l-1). Panel A endothelium dependent relaxation (EDR). Panel B endothelium independent relaxation to sodium nitroprusside (EIR). Panel C endothelium dependent relaxation factor responses (EDRF) in vessels incubated with L-NG-nitroarginine methyl ester (10-5 mol·l-1); Panel D endothelium dependent hyperpolarizating factor responses (EDHF) in vessels incubated with L-NAME (10-5 mol·l-1) plus apamin (AP, 10-6 mol·l-1) and charybotoxin (CTX, 10-5 mol·l-1). P values refer to ANOVA with repeated measures. Comparing HIV and control subjects at a single dose: *P<0.05, **P<0.01. |
