ARCHITECT          
Trial 1 Trial 2 Yr Vaccines       Ratio Western Blot        
VAC01 VAC05 16.6 vCP125 rgp160(CFA) vCP65 + 13.33 gp160 traces p55 weak p24 weak
VAC01 VAC05 16.7 vCP125 rgp160(CFA) vCP205 + 12.58 gp160 weak p55 weak p18 traces
VAC01 VAC05 16.6 vCP125 rgp160(CFA) vCP65 + 7.60 p68   p55   p18 traces
VAC01 VAC05 16.5 vCP125 rgp160(CFA) vCP65 + 5.63     p55      
VAC01 VAC05 16.6 vCP125 rgp160(CFA) vCP65 + 3.59 ND          
VAC01   17.7 vCP125 rgp160(alum)   + 3.02     p55 traces p18 traces
VAC01 VAC05 16.6 vCP125 rgp160(alum) vCP205 + 2.06     p55 traces p18 traces
VAC01 VAC05 16.6 vCP125 rgp160(CFA) vCP205 + 1.02 ND          
VAC01 VAC05 16.6 vCP125 rgp160(alum) vCP205 - 0.84 ND          
                           
VAC02   18.3 rgp160 (IFA) peptV3   + 14.04 gp160 weak p55 traces p18 traces
VAC02 VAC06 16.5 rgp160 (IFA) peptV3 vCP125 + 13.51 gp160 traces p55 traces    
VAC02 VAC06 16.4 rgp160 (alum)   vCP65 + 13.39 gp160 traces p55 traces    
VAC02   16.8 rgp160 (alum)     + 3.44     p55 weak p18 traces
VAC02 VAC06 16.5 rgp160 (alum) peptV3 vCP65 + 3.14     p55 weak p18 traces
VAC02   16.7 rgp160 (alum) peptV3   + 2.50 Negative        
VAC02   16.5 rgp160 (IFA) peptV3   + 2.03     p55 traces p18 traces
VAC02 VAC06 16.7 rgp160 (alum) peptV3 vCP65 + 1.96 Negative        
VAC02 VAC06 16.6 rgp160 (IFA) peptV3 vCP65 + 1.88     p55 traces p18 traces
VAC02 VAC06 17.0 rgp160 (IFA) peptV3 vCP125 + 1.72         p18 traces
VAC02 VAC06 16.5 rgp160 (alum) peptV3 vCP125 + 1.68 Negative        
VAC02   16.7 rgp160 (alum) peptV3   + 1.48 Negative        
VAC02   16.7 rgp160 (IFA) peptV3   - 0.97 ND          
VAC02 VAC06 16.7 rgp160 (alum)   vCP65 - 0.94 ND          
VAC02 VAC06 16.6 rgp160 (alum) peptV3 vCP125 - 0.84 ND          
VAC02 VAC06 17.4 rgp160 (IFA) peptV3 vCP65 - 0.66 ND          
VAC02 VAC06 16.3 rgp160 (alum)   vCP65 - 0.61 ND          
VAC02 VAC06 16.6 rgp160 (IFA) peptV3 vCP65 - 0.50 ND          
VAC02   16.8 rgp160 (alum)     - 0.32 ND          
VAC02   18.4 rgp160 (alum) peptV3   - 0.19 ND          
Yr: time in years since 1st injection; rgp160: recombinant gp160 ; CFA: complete Freund adjuvant; alum: aluminium hydroxide; IFA: incomplete Freund adjuvant; vCP125: ALVAC-HIV canarypox vector coding for gp160; vCP65: ALVAC canarypox vector coding for rabies G protein: vCP205: ALVAC-HIV canarypox vector coding for gp120; peptV3: gp120 V3 peptide loop; ND: not done
Table 1: Serological results obtained with the ARCHITECT and Western blot assays in the rgp160 group (rgp160 alone or combined with vCP recipients).
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