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ARCHITECT |
|
|
|
|
|
| Trial 1 |
Trial 2 |
Yr |
Vaccines |
|
|
|
Ratio |
Western Blot |
|
|
|
|
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(CFA) |
vCP65 |
+ |
13.33 |
gp160 |
traces |
p55 |
weak |
p24 |
weak |
| VAC01 |
VAC05 |
16.7 |
vCP125 |
rgp160(CFA) |
vCP205 |
+ |
12.58 |
gp160 |
weak |
p55 |
weak |
p18 |
traces |
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(CFA) |
vCP65 |
+ |
7.60 |
p68 |
|
p55 |
|
p18 |
traces |
| VAC01 |
VAC05 |
16.5 |
vCP125 |
rgp160(CFA) |
vCP65 |
+ |
5.63 |
|
|
p55 |
|
|
|
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(CFA) |
vCP65 |
+ |
3.59 |
ND |
|
|
|
|
|
| VAC01 |
|
17.7 |
vCP125 |
rgp160(alum) |
|
+ |
3.02 |
|
|
p55 |
traces |
p18 |
traces |
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(alum) |
vCP205 |
+ |
2.06 |
|
|
p55 |
traces |
p18 |
traces |
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(CFA) |
vCP205 |
+ |
1.02 |
ND |
|
|
|
|
|
| VAC01 |
VAC05 |
16.6 |
vCP125 |
rgp160(alum) |
vCP205 |
- |
0.84 |
ND |
|
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
| VAC02 |
|
18.3 |
rgp160 (IFA) |
peptV3 |
|
+ |
14.04 |
gp160 |
weak |
p55 |
traces |
p18 |
traces |
| VAC02 |
VAC06 |
16.5 |
rgp160 (IFA) |
peptV3 |
vCP125 |
+ |
13.51 |
gp160 |
traces |
p55 |
traces |
|
|
| VAC02 |
VAC06 |
16.4 |
rgp160 (alum) |
|
vCP65 |
+ |
13.39 |
gp160 |
traces |
p55 |
traces |
|
|
| VAC02 |
|
16.8 |
rgp160 (alum) |
|
|
+ |
3.44 |
|
|
p55 |
weak |
p18 |
traces |
| VAC02 |
VAC06 |
16.5 |
rgp160 (alum) |
peptV3 |
vCP65 |
+ |
3.14 |
|
|
p55 |
weak |
p18 |
traces |
| VAC02 |
|
16.7 |
rgp160 (alum) |
peptV3 |
|
+ |
2.50 |
Negative |
|
|
|
|
| VAC02 |
|
16.5 |
rgp160 (IFA) |
peptV3 |
|
+ |
2.03 |
|
|
p55 |
traces |
p18 |
traces |
| VAC02 |
VAC06 |
16.7 |
rgp160 (alum) |
peptV3 |
vCP65 |
+ |
1.96 |
Negative |
|
|
|
|
| VAC02 |
VAC06 |
16.6 |
rgp160 (IFA) |
peptV3 |
vCP65 |
+ |
1.88 |
|
|
p55 |
traces |
p18 |
traces |
| VAC02 |
VAC06 |
17.0 |
rgp160 (IFA) |
peptV3 |
vCP125 |
+ |
1.72 |
|
|
|
|
p18 |
traces |
| VAC02 |
VAC06 |
16.5 |
rgp160 (alum) |
peptV3 |
vCP125 |
+ |
1.68 |
Negative |
|
|
|
|
| VAC02 |
|
16.7 |
rgp160 (alum) |
peptV3 |
|
+ |
1.48 |
Negative |
|
|
|
|
| VAC02 |
|
16.7 |
rgp160 (IFA) |
peptV3 |
|
- |
0.97 |
ND |
|
|
|
|
|
| VAC02 |
VAC06 |
16.7 |
rgp160 (alum) |
|
vCP65 |
- |
0.94 |
ND |
|
|
|
|
|
| VAC02 |
VAC06 |
16.6 |
rgp160 (alum) |
peptV3 |
vCP125 |
- |
0.84 |
ND |
|
|
|
|
|
| VAC02 |
VAC06 |
17.4 |
rgp160 (IFA) |
peptV3 |
vCP65 |
- |
0.66 |
ND |
|
|
|
|
|
| VAC02 |
VAC06 |
16.3 |
rgp160 (alum) |
|
vCP65 |
- |
0.61 |
ND |
|
|
|
|
|
| VAC02 |
VAC06 |
16.6 |
rgp160 (IFA) |
peptV3 |
vCP65 |
- |
0.50 |
ND |
|
|
|
|
|
| VAC02 |
|
16.8 |
rgp160 (alum) |
|
|
- |
0.32 |
ND |
|
|
|
|
|
| VAC02 |
|
18.4 |
rgp160 (alum) |
peptV3 |
|
- |
0.19 |
ND |
|
|
|
|
|
Yr: time in years since 1st injection; rgp160: recombinant gp160 ; CFA: complete Freund adjuvant; alum: aluminium hydroxide; IFA: incomplete Freund adjuvant; vCP125:
ALVAC-HIV canarypox vector coding for gp160; vCP65: ALVAC canarypox vector coding for rabies G protein: vCP205: ALVAC-HIV canarypox vector coding for gp120;
peptV3: gp120 V3 peptide loop; ND: not done |
