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| Figure 6: Loss of intestinal Th17 or Th22 cells correlates with preferential depletion of intestinal CD4 T cells during SIV infection in macaques. (A) Viral load in plasma in macaques post SIV infection (n=11). (B) Longitudinal examination of circulating CD4 T cells in macaques from primary to chronic SIV infection (n=5). (C and D) Positive correlations of Th17 or Th22 cells with total CD4 T cells in intestinal mucosal tissues. (E) Positive correlations between Th17 and Th22 cells in intestinal mucosal tissues. Uninfected, n=41; chronic SIV, n=15. (F) Inverse correlation of intestinal Th22 cells with plasma viral loads in chronic SIV infection (n=12). |
