HIV-positive HIV-unknown Univariable logistic regression
(GEE)
Multivariable logistic regression (GEE)a
  n=1087 n=255 OR (95% CI) p-value (OR (95% CI) p-value
Presentation year            
Before 2010 731 (67.7%) 196 (77.2%) 1.0   1.0  
During 2010 349 (32.3%) 58 (22.8%) 1.6 (1.2, 2.2) 0.003 1.0 (0.7, 1.5) 0.989
Episode number            
1st 1023 (94.1%) 254 (99.6%) Not included   Not included  
2nd 58 (5.3%) 1 (0.4%)        
3rd 6 (0.6) 0 (0.0%)        
Clinic in London            
No 316 (29.1%) 100 (39.2%) 1.0   1.00  
Yes 771 (70.9%) 155 (60.8%) 1.5 (1.2, 2.1) 0.003 1.4 (0.9, 2.0) 0.099
Duration of symptoms            
Week or less 377 (34.7%) 65 (25.5%) 1.0   1.00  
More than a week 500 (46.0%) 141 (55.3%) 0.6 (0.5, 0.8) 0.002 0.5 (0.3, 0.8) 0.002
Unknown 210 (19.3%) 49 (19.2%) 0.7 (0.5, 1.1) 0.146 0.7 (0.4, 1.3) 0.304
Reasons for attending            
Symptoms            
No 139 (12.9%) 31 (12.2%) 1.0   Not included  
Yes 925 (85.1%) 218 (85.5%) 0.9 (0.6, 1.4) 0.783    
Unknown 23 (2.1%) 6 (2.4%) 0.8 (0.3, 2.1) 0.710    
Contact tracing            
No 980 (90.2%) 229 (89.8%) 1.0   Not included  
Yes 84 (7.7%) 20 (7.8%) 1.0 (0.6, 1.6) 0.927    
Unknown 23 (2.1%) 6 (2.4%) 0.9 (0.4, 2.1) 0.769    
Routine STI screen            
No 988 (90. 9%) 232 (91.0%) 1.0   Not included  
Yes 76 (7.0%) 17 (6.7%) 1.1 (0.6, 1.8) 0.849    
Unknown 23 (2.1%) 6 (2.4%) 0.9 (0.4, 2.1) 0.779    
Referral            
No 1,033 (95.0%) 233 (91.4%) 1.0   1.0  
Yes 31 (2.6%) 16 (6.3%) 0.4 (0.2, 0.8) 0.011 0.3 (0.1, 0.8) 0.015
Unknown 23 (2.1%) 6 (2.4%) 0.8 (0.4, 2.0) 0.713 0.6 (0.2, 1.6) 0.292
Symptomsreported            
None 60 (5.5%) 11 (4.3%) 1.0   1..0  
Only Genital 41 (3.8%) 24 (9.4%) 0.3 (0.1, 0.7) 0.005 0.5 (0.2, 1.2) 0.107
Only Rectal 758 (69.7%) 147 ( 57.7%) 1.0 (0.5, 1.8) 0.880 1.2 (0.5, 2.8) 0.600
Both 172 (15.8%) 54 (21.2%) 0.6 (0.3, 1.2) 0.140 0.7 (0.3, 1.7) 0.403
Unknown 56 (5.2%) 19 (7.5%) 0.6 (0.3, 1.3) 0.167 0.9 (0.3, 2.4) 0.810
Site of infection            
Rectal 454 (41.8%) 63 (29.3%) 1.0   1.0  
Genital 10 (0.9%) 5 (2.3%) 0.3 (0.1. 0.9) 0.032 0.6 (0.2, 2.1) 0.377
Both or other 8 (0.7%) 3 (1.2%) 0.4 (0.1, 1.5) 0.182 0.6 (0.1, 2.4) 0.428
Unknown 614 (56.5%) 144 (97.0%) 0.5 (0.4, 0.7) <0.001 0.6 (0.4, 0.9) 0.015
Systemic symptom            
No 750 (69.0%) 186 (72.9%) 1.0   1.0  
Yes 292 (26.9%) 57 (22.4%) 1.3 (0.9, 1.7) 0.150 1.6 (1.0, 2.4) 0.034
Unknown 45 (4.1%) 12 (4.7%) 0.9 (0.5, 1.8) 0.833 1.5 (0.6, 3.3) 0.360
Other STIb            
No 664 (61.1%) 143 (56.1%) 1.0   1.0  
Yes 315 (29.0%) 72 (28.2%) 1.0 (0.7, 1.3) 0.718 1.2 (0.8, 1.8) 0.404
Unknown 108 (9.9%) 40 (15.7%) 0.59 (0.4, 0.9) 0.010 0.5 (0.3, 0.9) 0.013
Hepatitis C (PCR)            
No 410 (37.7%) 57 (22.4%) 1.0   Not included  
Yes 138 (12.7%) 3 (1.2%) 5.9 (2.0, 17.5) 0.001    
Unknown 539 (49.6%) 195 (76.5%) 0.4 (0.3, 0.5) <0.001    
a Multivariable model adjusted also for form delay (days between presentation to the clinic and filling in the surveillance form)
b No other STIs versus syphilis, non-specific urethritis, warts, herpes, hepatitis B and some less common STIs mentioned in the text field.
Table 1: Clinical variables and their association with HIV status in the LGV Enhanced Surveillance data.
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