Target Site Antibodies Glycan Dependent Quaternary Structure Dependent Coreceptor association References
gp120 CD4 binding site b12, NIH45-46, VRC01, PGV04, 3BNC117 No No Unknown [101-104]
gp120 outer domain 2G12, PGT 135-137 Yes No Unknown [105,106]
gp120 V3 PGT 121-123; PGT 125-128, PGT 130-131 Yes No PGT 128 selects X4 tropism [98,106]
gp120 V1V2 PGT 141-145; PG9/PG16; CH01-04 Yes Yes PG9/PG16 : R5 tropic [98, 106-108]
gp41 MPER 2F5; 4E10; 10E8 No No Unknown [109-113]
gp120:gp41 cleaved trimer PGT 151-158 Yes Yes   [114,115]
Table 3: Broadly Neutralizing Antibodies against HIV.
Goto home»