| Target Site |
Antibodies |
Glycan Dependent |
Quaternary Structure Dependent |
Coreceptor association |
References |
| gp120 CD4 binding site |
b12, NIH45-46, VRC01, PGV04, 3BNC117 |
No |
No |
Unknown |
[101-104] |
| gp120 outer domain |
2G12, PGT 135-137 |
Yes |
No |
Unknown |
[105,106] |
| gp120 V3 |
PGT 121-123; PGT 125-128, PGT 130-131 |
Yes |
No |
PGT 128 selects X4 tropism |
[98,106] |
| gp120 V1V2 |
PGT 141-145; PG9/PG16; CH01-04 |
Yes |
Yes |
PG9/PG16 : R5 tropic |
[98, 106-108] |
| gp41 MPER |
2F5; 4E10; 10E8 |
No |
No |
Unknown |
[109-113] |
| gp120:gp41 cleaved trimer |
PGT 151-158 |
Yes |
Yes |
|
[114,115] |
|
