Infant Mutation Week Maternal Study Regimen (Duration) Zidovudine Breast Fed   NVP NRTI   Antenatal Infant   1 K103N   2 Lopinavir/ritonavir (7 days) Yes Yes NO   V106A   2   Y181C   2,4   G190A   2,4     K70R* 2 2 V106A None 2,4 Lopinavir/ritonavir (21 days) No No Yes   Y181C   2-97 3 K103N   4 Lopinavir/ritonavir (21 days) No No Yes 4 V106A None 4 Lopinavir/ritonavir (21 days) No yes yes 5 None K65R   Emtricitabine/tenofovir (21 days) No No Yes

Table 1: New nevirapine and nucleoside reverse transcriptase inhibitor mutations detected among intrauterine - infected infants. Note: NVP: Nevirapine; NRTI: Nucleoside Reverse Transcriptase Inhibitor; *Mother concordant for K70R mutation.

Goto home»