Characteristics TDF Stopped
Yes  (N=49)           No (N=31)       P value*
Age in years, median (IQR) 55 (47-61) 55 (47-61) 0.7
Weight in kg, median (IQR) 75 (67-85) 76 (64 -93) 0.86
Race, n (%)
Non Hispanic – White 9 (18) 6 (19) NA
Non Hispanic – Black 38 (76) 21 (68)
Other 2 (4) 4 (13)
Gender, n (%)
Female 6 (12) 7 (23) 0.22
Male 43 (88) 24 (77)
Baseline sCr in mg/dl, median (IQR)2 1 (1-1) 1 (1-1) 0.13
Baseline GFR in ml/min, median (IQR)2 90 (70-107) 87 (79-119) 0.7
sCr in mg/dl before HLA test, median (IQR)3 1 (1-2) 1 (1-1) 0.02
GFR in ml/min before HLA test, median(IQR)3 67 (57-86) 83 (66 -96) 0.05
sCr in mg/dl at HLA testing, median (IQR)4 1.7 (1.4-2) 1.6 (1.3-2) 0.26
GFR in ml/min at HLA testing, median (IQR)4 52 (44-61) 60 (50-74) 0.06
Recovered Renal Function, n (%)
Yes 37 (76) 17 (55) 0.3
No 12 (24) 14 (45)
Chronic Kidney Disease, n (%)
Yes 8 (16) 2 (6) 0.3
No 41 (84) 29 (94)
HCV Antibody status, n (%)
Positive 12 (24) 8 (26) 0.89
Negative 37 (76) 23 (74)
Diabetes Mellitus, n (%)
Yes 9 (18) 3 (10) 0.35
No 40 (82) 28 (90)
Hypertension, n (%)
Yes 23 (47) 12 (39) 0.46
No 26 (53) 19 (61)
Nephrotoxic Drugs, n (%)
Yes 26 (53) 16 (52) 0.9
No 23 (47) 15 (48)
HIV-1 PVL at HLA test, n (%)
≥ 75 log10 copies/ml 10 (21) 9 (31) 0.31
< 75 log10 copies/ml 38 (79) 20 (69)
CD4 cell count at HLA test, n (%)
≤ 200 cells/uL 9 (19) 7 (24) 0.6
> 200 cells/uL 38 (81) 22 (76)
Table 1: Participant Demographics and Clinical Characteristics by TDF Discontinuation (n=80)1. 1Due to missing values for some variables, not all rows add up to total n=80; 2 Value before starting TDF; 3 Value preceding HLA test; 4 Value at HLA test; *Chi-square was used to examine the relationship between serum creatinine and categorical variables, whereas the non-parametric Kruskal-Wallis test was used to examine the difference between continous variable. Fisher's Exact test was used where expected cell value was less than. TDF: Tenofovir; IQR: Interquartile Range; sCr: Serum Creatinine; GFR: Glomerular Filtration Rate (Cockroft-Gault); HCV: Hepatitis C Virus; PVL: Plasma Viral Load.
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